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Dosage must be adjusted according to each patient's needs. Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily. Nifedipine extended release tablets should be swallowed whole and should not be bitten or divided. Dolasetron: In patients taking dolasetron by the oral or intravenous route and nifedipine, no effect was shown on the clearance of hydrodolasetron. Dantas SM. Menopausal synptoms and alternative medicine. Use this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with do not feel sick.

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Constantino, A. Hypertension in mother and baby linked to ingestion of Chinese herbal medicine. CYP3A and may decrease exposure to nifedipine. Mansuri, S. M. Effect of certain volatile oils on ejaculated human spermatozoa.

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There are no adequate and well-controlled studies in pregnant women. Some patients with exertional angina pectoris have reported increased chest pain after taking nifedipine. This may, however, reflect progressive disease rather than drug effect. Ventricular fibrillation has rarely been reported. Subsequent titration to higher or lower doses may be necessary and should be initiated as clinically warranted. Experience with doses greater than 90 mg in patients with angina is limited. Therefore, doses greater than 90 mg should be used with caution and only when clinically warranted.

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Lawrence B. Progress in essential oils. Before having surgery, tell your doctor or dentist that you are taking this medication. Oikawa, H. Antimicrobial effect of spices and herbs on Vibrio parahaemolyticus. Int.



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Chalier, P. Antimicrobial activity of carvacrol related to its chemical structure. Lett. Hildebrand, C. N. and DeRenzis, F. A. Effect of periodontal dressings on fibroblasts in vitro. J Periodontal Res. The risk of and lightheadedness from is especially high if you use too much ointment at one time. Willershausen, B. In vitro analysis of the cytotoxicity and the antimicrobial effect of four endodontic sealers. Head Face. Begin, A. Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms. Int. Kortsaris, A. H. Antiproliferative effect of mineral trioxide aggregate, zinc oxide-eugenol cement, and glass-ionomer cement against three fibroblastic cell lines. J Endod. Do NOT take more than the recommended dose without checking with your doctor. Lee, K. G. and Shibamoto, T. Inhibition of malonaldehyde formation from blood plasma oxidation by aroma extracts and aroma components isolated from clove and eucalyptus. Food Chem. Ogura, H. Application of the MTT colorimetric assay to measure cytotoxic effects of phenolic compounds on established rat dental pulp cells. J Dent. Care should be taken when dispensing nifedipine extended release to assure that the extended release dosage form has been prescribed. Cirrhotic patients: Careful monitoring and dose reduction may be needed. Initiating therapy with the lowest available dose should be considered. It is recommended that Adalat CC be administered orally once daily on an empty stomach. Adalat CC is an extended release dosage form and tablets should be swallowed whole, not bitten or divided. In general, titration should proceed over a 7-14 day period starting with 30 mg once daily. Upward titration should be based on therapeutic efficacy and safety. The usual maintenance dose is 30 mg to 60 mg once daily. Titration to doses above 90 mg daily is not recommended. Adalat CC tablets consist of an external coat and an internal core.



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Walker, M. J. Effect of a proprietary rubefacient "Tiger Balm" on rabbit skin. Food Chem. Mabrouk, S. S. and El Shayeb, N. M. Inhibition of aflatoxin formation by some spices. Due to the possibility of an excessive drop in blood pressure which could harm the mother and fetus, blood pressure must be carefully monitored in pregnant women when administering nifedipine in combination with intravenous magnesium sulfate. Cai, L. and Wu, C. D. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J Nat. CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered. Careful monitoring and dose adjustment may be necessary; consider initiating nifedipine at the lowest dose available if given concomitantly with these medications. Wells CD, Luckritz TC, Rady MY, Zornik JM, Leighton JA, Patel BM "Bezoar formation requiring endoscopic removal after intentional overdose of extended-release nifedipine. Lee, K. T. Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells. Cancer Lett. Goy SY and Loh KC. Gynaecomastia and the herbal tonic "Dong Quai". McDonald, J. W. and Heffner, J. E. Eugenol causes oxidant-mediated edema in isolated perfused rabbit lungs. Am Rev Respir. Faroque, A. B. Antibacterial activity of clove extracts against phagogenic strains including clinically resistant isolates of Shigella and Vibrio cholerae. Pak. Wash your hands immediately after using Lidocaine Cream, unless your hands are part of the treated area. Lewbart, G. A. Comparative efficacy of tricaine methanesulfonate and clove oil for use as anesthetics in red pacu Piaractus brachypomus. Am J Vet. etodolac



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Morton C, Hickey-Dwyer M "Cortical blindness after nifedipine treatment. PROTECT FROM MOISTURE AND HUMIDITY. The mother's water breaking before start. Dutkiewicz, J. Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases. Ann Agric. If the patient's condition permits, sufficient time at least 36 hours should be allowed for nifedipine to be washed out of the body prior to surgery. Take nifedipine by mouth with or without food. This medication passes into breast milk. Consult your doctor before breast-feeding. Bartolo, R. G. Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. J Appl. Noxafil posaconazole US prescribing information. Known hypersensitivity to nifedipine. Some medical conditions may interact with nifedipine. Varel, V. H. and Miller, D. L. Eugenol stimulates lactate accumulation yet inhibits volatile fatty acid production and eliminates coliform bacteria in cattle and swine waste. J Appl. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems. Myrhed M, Wiholm B-E "Nifedipine: a survey of adverse effects. Jalava KM, Olkkola KT, Neuvonen PJ. Itraconazole greatly increases plasma concentrations and effects of felodipine. Not feeling well, including having a fever you can't explain and being overly tired. zudo.info domperidone



List of nifedipine side effects

Although relatively minor, the negative inotropic side effect of nifedipine may be important in patients with a history of congestive heart failure. Allen, K. and Cornforth, D. Effect of chelating agents and spice-derived antioxidants on myoglobin oxidation in a lipid-free model system. If you need surgery, tell the surgeon ahead of time that you are using nifedipine. You may need to stop using the medicine for a short time. Adalat CC is suggested. Wang, Z. Q. Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. J Tradit. Manga P, Vythilingum "Unstable angina precipitated by nifedipine. Jana, M. Antibacterial activity of some Moroccan medicinal plants. Phytother. Hong CH, Hur SK, Oh OJ, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase COX-2 and nitric oxide synthase iNOS in cultured mouse macrophage cells. walmart pharmacy and cycrin



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The interaction with high dose fentanyl appears to be due to the combination of nifedipine and a beta blocker, but the possibility that it may occur with nifedipine alone, with low doses of fentanyl, in other surgical procedures, or with other narcotic analgesics cannot be ruled out. In nifedipine-treated patients where surgery using high dose fentanyl anesthesia is contemplated, the physician should be aware of these potential problems and, if the patient's condition permits, sufficient time at least 36 hours should be allowed for nifedipine to be washed out of the body prior to surgery. During an exam, a doctor can also find out whether another condition may be causing the fissure. Nifedipine is metabolized by CYP3A4. Co-administration of nifedipine with phenytoin, an inducer of CYP3A4, lowers the systemic exposure to nifedipine by approximately 70%. Avoid co-administration of nifedipine with phenytoin or any known CYP3A4 inducer or consider an alternative antihypertensive therapy. Choi, I. G. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. Use nifedipine as directed by your doctor. Check the label on the medicine for exact dosing instructions. Ameen M, Harman KE, Black MM "Pemphigoid nodularis associated with nifedipine. Zhu D, Lu Y, and Zheng Q. Isolation of eugenol from volatile oil of cloves by inclusion method. Adalat CC. This was an isolated finding and it rarely resulted in values which fell outside the normal range. Rare instances of allergic hepatitis have been reported with nifedipine treatment. In controlled studies, Adalat CC did not adversely affect serum uric acid, glucose, cholesterol or potassium. Ahn, Y. J. Acaricidal activity of clove bud oil compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus Acari: Pyroglyphidae. J Agric. Ramos A, Visozo A, Piloto J, et al. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. Sit in a tub filled with a few inches of warm water for 20 minutes, 2 or 3 times a day. Natural compounds fight oral pathogens. Check the labels on all your medicines such as cough-and-cold products, diet aids because they may contain ingredients that could increase your heart rate and worsen chest pain including caffeine, pseudoephedrine, phenylephrine. Ask your pharmacist about using these products safely. Grossman E, Messerli FH, Grodzicki T, Kowey P "Should a moratorium be placed on sublingual nifedipine capsules given for hypertensive emergencies and pseudoemergencies?



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Gastrointestinal obstruction resulting in hospitalization and surgery, including the need for bezoar removal, has occurred in association with nifedipine extended release tablets, even in patients with no prior history of gastrointestinal disease. Pemberton R. THE TRINIDAD BOTANIC GARDENS AND COLONIAL RESOURCE DEVELOPMENT, 1818-1899. There have been rare reports of obstructive symptoms in patients with known strictures in association with the ingestion of nifedipine extended release tablets. Bezoars can occur in very rare cases and may require surgical intervention. Jorkjend, L. and Skoglund, L. A. Effect of non-eugenol- and eugenol-containing periodontal dressings on the incidence and severity of pain after periodontal soft tissue surgery. J Clin Periodontol. Jagdale, G. B. and Grewal, P. S. Identification of alternatives for the management of foliar nematodes in floriculture. Pest. Abe, S. The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box. J Infect. Perrucci, S. Efficacy of an essential oil of Eugenia caryophyllata against Psoroptes cuniculi. Exp. Nifedipine may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use nifedipine with caution. If you are self-treating with this medication, carefully read the package instructions to be sure it is right for you before you start using this product. Some products have similar brand names but different active ingredients with different uses. Taking the wrong product could harm you. Ask your if you have any questions about your product or its use. GI disorder, GI hemorrhage, GI irritation, gum disorder, and gum hemorrhage less than 1%. Rarely, bezoars have been reported in patients taking extended release nifedipine as Procardia XLR. Gastrointestinal obstruction resulting in hospitalization and surgery including the need for bezoar removal has been reported with Procardia XLR even in patients with no known gastrointestinal disease. Tablet adherence to the GI wall with ulceration has been reported with Procardia XLR; some cases required hospitalization and intervention. Endo, T. Trapping effect of eugenol on hydroxyl radicals induced by L-DOPA in vitro. Chem. Zhao KJ, Dong TT, Tu PF, et al. Molecular genetic and chemical assessment of radix Angelica Danggui in China. order diphenhydramine basket



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Nifedipine is excreted in human milk. Cameron, N. E. Effects of eugenol on nerve and vascular dysfunction in streptozotocin-diabetic rats. Kim, E. C. Human periodontal ligament cell response to a newly developed calcium phosphate-based root canal sealer. J Endod. Tufik, S. Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? PROM. When it happens before 37 weeks of pregnancy, it is called preterm premature rupture of membranes, or pPROM. Huysteen, G. W. Poisoning with Boophane disticha: a forensic case. Hum. An is a tear in the delicate tissue that lines your anal canal. They usually cause bleeding and severe pain. drontal to purchase in canada



How to use nifedipine

If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same times each day. It is important to taper beta blockers if possible, rather than stopping them abruptly before beginning nifedipine. Patients recently withdrawn from beta blockers may develop a withdrawal syndrome with increased angina, probably related to increased sensitivity to catecholamines. There has been one reported case of massive overdosage with tablets of another extended release formulation of nifedipine. The main effects of ingestion of approximately 4800 mg of nifedipine in a young man attempting suicide as a result of cocaine-induced depression was initial dizziness, palpitations, flushing, and nervousness. Within several hours of ingestion, nausea, vomiting, and generalized edema developed. No significant hypotension was apparent at presentation, 18 hours post ingestion. Blood chemistry abnormalities consisted of a mild, transient elevation of serum creatinine, and modest elevations of LDH and CPK, but normal SGOT. Vital signs remained stable, no electrocardiographic abnormalities were noted and renal function returned to normal within 24 to 48 hours with routine supportive measures alone. No prolonged sequelae were observed. Nifedipine is not removed by hemodialysis or peritoneal dialysis. A supplemental dose is not necessary. Venturini, L. and Sordi, G. A. Radioactivity in and committed effective dose from some Brazilian foodstuffs. Health Phys. You pass a large stool. Hemaiswarya, S. and Doble, M. Synergistic interaction of eugenol with antibiotics against Gram negative bacteria. Phytomedicine. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. elimite



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Kadey M. Lost in spice. More evidence is needed to rate the effectiveness of dong quai for these uses. Mandrell, R. E. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. J Food Prot. H7 and Salmonella enterica in apple juice. J Agric. Fernandes, P. D. Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in mice. Research progresses in the chemistry and pharmacology of Angelica sinensis Oliv. Adalat CC is less bioavailable than the immediate release formulation. Co-administration of nifedipine with grapefruit juice results in up to a 2-fold increase in AUC and C max, due to inhibition of CYP3A related first-pass metabolism. Ingestion of grapefruit and grapefruit juice should be avoided while taking nifedipine. Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Singh S and Fogueria LR. Investigation of effects of terpene skin penetration enhancers on stability and biological activity of lysozyme. Dosage is based on the product you are taking and your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed without your doctor's approval.



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Due to the nonabsorbable shell of Procardia XL R patients may notice the empty tablet in their stools. Ginseng is widely used for its antistress, anticancer, immune system modulation, cardiovascular, CNS, and hormonal effects, and for improvement of athletic performance, but these uses have not been confirmed by clinical trials. What is the recommended dosage? This product may help you fall asleep faster and decrease the number of times you awaken during the night. It may also help you for a longer time. is a substance that your body normally makes. It is thought to help your body's regular daily cycle, production, and patterns. Mermigas, M. E. Evaluation of eugenol for mutagenicity by the mouse micronucleus test. J Oral Pathol. Of these, only edema and headache were more common in nifedipine extended release patients than placebo patients. Nifedipine was administered orally to rats for two years and was not shown to be carcinogenic. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 5 times the maximum recommended human dose. There is a literature report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro. In vivo mutagenicity studies were negative. The only way to completely avoid anal sex risks is to abstain from anal sex. If you engage in anal sex, it is always important to use a to protect against the spread of infections and diseases. The doctor inserts a gloved finger into the anal canal. Other drugs may interact with nifedipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Amprenavir, atanazavir, delavirine, fosamprinavir, indinavir, nelfinavir and ritonavir, as CYP3A inhibitors, can inhibit the metabolism of nifedipine and increase the exposure to nifedipine. Caution is warranted and clinical monitoring of patients recommended. Nifedipine should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. Relax prior to insertion of the penis to help reduce the risk of tears. Taking a warm bath before anal sex or lying on your may make insertion easier. Kumar, P. and Singh, D. K. Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata. AUC relative to nifedipine monotherapy. In view of the high variability of nifedipine pharmacokinetics, the clinical significance of this finding is unknown. Heo, M. Y. Biological screening of 100 plant extracts for cosmetic use II: anti-oxidative activity and free radical scavenging activity. Int. generic eskazole purchase canada



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Jr. Essential oils against foodborne pathogens and spoilage bacteria in minced meat. Foodborne. Place each dose on the and allow to dissolve completely, then swallow it with or with water. Branan B, Butcher J, and Olsen L. Using Ozone in Organic Chemistry Lab: The Ozonolysis of Eugenol. Heinig R, Adelmann HG, Ahr G. The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine. The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Nifedipine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, stit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. pantozol



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You have had a uterine surgery in the past. Strong contractions may cause the uterus to rupture. Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp. Older adults should discuss the risks and benefits of this medication with their doctor or pharmacist, as well as other possibly safer forms of nifedipine such as the long-acting tablets. Xue JX, Jiang Y, and Yan YQ. Effect and mechanism of antiplatelet aggregation of Cyperus rotundus, Ligusticum chuanxiong and Paeonia lactiflora in combination with Astragalus membranaceus and Angelica sinensis. Many experts believe that extra tension in the two muscular rings sphincters controlling the may be a cause of fissures. The outer anal sphincter is under your conscious control. But the inner sphincter is not. This muscle is under pressure, or tension, all of the time. If the pressure increases too much, it can cause spasm and reduce flow to the anus, leading to a fissure. This pressure can also keep a fissure from healing. What are the symptoms? Nassar, M. I. Flavonoid triglycosides from the seeds of Syzygium aromaticum. Carbohydr. Zidek W, Spiecker C, Knaup G, Steindl L, Breuer HWM "Comparison of the efficacy and safety of nifedipine coat-core versus amlodipine in the treatment of patients with mild-to-moderate essential hypertension. Oh, S. B. Eugenol inhibits calcium currents in dental afferent neurons. J Dent. Owen P and Johns T. Antioxidants in Medicines and Spices as Cardioprotective Agents in Tibetan Highlanders. Not all drinks are good choices for staying hydrated. Too much alcohol can dehydrate you. Also, although a caffeinated drink may help you go to the bathroom, too much can dehydrate you as well. The 30 mg tablet is imprinted with G and 30 on one side of the tablet and blank on the other side. Efferth, T. The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action. Arch. Abdel-Fatah MK, El-Hawa MA, Samia EM, and et al. Antimicrobial activities of some local medicinal plants. Mahady, G. B. Extracts of spice and food plants from Thai traditional medicine inhibit the growth of the human carcinogen Helicobacter pylori. Ranitidine produced smaller, non-significant increases. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.



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Segura, J. J. and Jimenez-Rubio, A. Effect of eugenol on macrophage adhesion in vitro to plastic surfaces. Endod. Nefazodone, a CYP3A inhibitor, can inhibit the metabolism of nifedipine and increase the exposure to nifedipine during concomitant therapy. Blood pressure should be monitored and a reduction of the dose of nifedipine considered. Banerjee, S. and Das, S. Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis. Asian Pac. Laskin, D. M. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac.

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Drink plenty of fluids. This test may be done when results from a nonstress test or a biophysical profile are not in the normal range. This is used to prevent certain types of . It may allow you to more and decrease the frequency of angina attacks. Nifedipine belongs to a class of known as channel blockers. It works by relaxing vessels so can flow more easily. This medication must be taken regularly to be effective. It should not be used to treat attacks of chest pain when they occur. Use other medications such as sublingual to relieve attacks of chest pain as directed by your doctor. Consult your doctor or for details.

In vivo mutagenicity studies were negative

Contraindications have not been established aside from known hypersensitivity. Bian, Z. In vitro activity of eugenol against Candida albicans biofilms. If you need surgery, tell the surgeon ahead of time that you are using Adalat CC. You may need to stop using the medicine for a short time. Cases of urticarial eruptions and erythema multiforme, often associated with other findings of hypersensitivity, have been reported. Kim, D. H. Anti-Helicobacter pylori activity of herbal medicines. Biol Pharm Bull.

What are the possible side effects of nifedipine

Toner M, White A, Moriarty J, Clancy L "Allergic urticarial eruption, leukocytosis and abnormal liver function tests following nifedipine administration. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Warnings: Pregnancy and breast-feeding: Taking dong quai by mouth during pregnancy is POSSIBLY UNSAFE for the baby. Dong quai seems to affect the muscles of the uterus. There is also one report linking an herbal combination that contained dong quai with birth defects in a baby whose mother took the combination during the first three months of pregnancy.

Evans, C. S. Cytotoxicity of clove Syzygium aromaticum oil and its major components to human skin cells. Cell Prolif. Takagi, N. Pharmacological studies on the anti-inflammatory action of phenolic compounds. J Dent. Continued How is preterm labor diagnosed? Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Ozaki, Y. and Ma, J. P. Inhibitory effects of tetramethylpyrazine and ferulic acid on spontaneous movement of rat uterus in situ.

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